Clinic of Cardiovascular Diseases, University of Genoa, Genoa, Italy. IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, Genoa, Italy. Department of Internal Medicine, First Clinic of Internal Medicine, University of Genoa, Genoa, Italy. Department of Internal Medicine, and Centre of Excellence for Biomedical Research (CEBR), First Clinic of Internal Medicine, University of Genoa, Genoa, Italy. IRCCS Ospedale Policlinico San Martino Genoa, Genoa, Italy. Department of Internal Medicine, Geriatric Unit, University of Genoa, Genoa, Italy.